A Survey on Machine Learning Techniques for Multimodal Biomedical Signal Processing

In recent years, there has been a significant growth in the development of machine learning algorithms towards better experience in patient care. In this paper, a contemporary survey on the deep learning and machine learning techniques used in multimodal signal processing for biomedical applications is presented. Specifically, an overview of the preprocessing approaches and the algorithms proposed for five major biomedical applications are presented, namely detection of cardiovascular diseases, retinal disease detection, stress detection, cancer detection and COVID-19 detection. In each case, processing on each multimodal data type, such as an image or a text is discussed in detail. A list of various publicly available datasets for each of these applications is also presented. © 2023 IEEE.

Recent Advances in Sensor Technology for Biomedical Applications: A Review

Sensor technology has become an integral part of the diagnosis, monitoring, therapeutic and surgical areas of medical science. Various sensors like glucose biosensors for diagnosis of diabetes mellitus or fluorescent sensors for gene expression and protein localization have become a common part of the biomedical field. Due to their widespread applications, various advances and improvements have taken place in medical sensor technology which has led to an increase in the ease and accuracy of diagnosis as well as treatment of diseases. This review article aims at studying various novel and innovative developments in biosensors, fibre optic sensors, sensors used for microelectromechanical systems, flexible sensors and wearable sensors. This article also explores new sensing methodologies and techniques in different medical domains like dentistry, robotic surgery and diagnosis of severe life-threatening diseases like cancer and diabetes. Various sensors and systems used for rapid detection of the SARS-CoV-2 virus which is responsible for the COVID-19 pandemic have also been discussed in this article. Comparison of novel sensor-based systems for detection of various medical parameters with traditional techniques is included. Further research is necessary to develop low cost, highly accurate and easy-to-use medical devices with the help of these innovative sensor technologies. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

Covid-19 Variants Detection and Classification Using Self Proposed Two stage MNN-2: Robust Comparison with Yolo V5 and Faster R-CNN

Covid-19 is unpredictable evolutionary discipline which requires continuous advancements for its appropriate Detection and Classifications which can be helpful for bio-medical stream. In this research, two dimensions are covered that is detection and classification using self-proposed 2 stage learning detector. Detection of different variants of Covid-19 are performed using images of CT-Scan and X-Rays of effected lungs. Furthermore, classification of different variants is carried out. Dataset of 27000 indigenous images were used for detection and classification purposed. Moreover, in depth survey and comparison is carried out with state-of-the-art Yolo v5 single state detector and Faster R-CNN 2 stage detector. Accuracy analysis of self-proposed 2 stage detector was 91.66% and 87.9% for detection and classification in comparison with YOLOv5 which had accuracy of 92.8% and 87.175% for detection and classification. Moreover, in comparison with Faster R-CNN which had accuracy of 94.8% and 87% The training analysis was performed on Nvidia T4 (16GB GDDR6). Self-proposed MNN-2 superseded Yolov5 and faster R-CNN in real time video analysis with least real time rate at FPS 30 at duration of 72 min video. © 2022 IEEE.

The Role of Hsp70 in Adaptation to Adverse Conditions and Its Possible Medical Application.

In the present era of global warming and dramatically increased environmental pollution posing a threat to animal life, the understanding and manipulation of organisms' resources of stress tolerance is apparently a question of survival. Heat stress and other forms of stressful factors induce a highly organized response of organisms at the cellular level where heat shock proteins (Hsps) and in particular Hsp70 family of chaperones are among the major players in the protection from the environmental challenge. The present review article summarizes the peculiarities of the Hsp70 family of proteins protective functions being a result of many millions of years of adaptive evolution. It discusses the molecular structure and specific details of hsp70 gene regulation in various organisms, living in diverse climatic zones, with a special emphasis on the protective role of Hsp70 in adverse conditions of the environment. The review discusses the molecular mechanisms underlying Hsp70-specific properties that emerged in the course of adaptation to harsh environmental conditions. This review also includes the data on the anti-inflammatory role of Hsp70 and the involvement of endogenous and recombinant Hsp70 (recHsp70) in proteostatic machinery in various pathologies including neurodegenerative ones such as Alzheimer's and Parkinson's diseases in rodent model organisms and humans in vivo and in vitro. Specifically, the role of Hsp70 as an indicator of disease type and severity and the use of recHsp70 in several pathologies are discussed. The review discusses different roles exhibited by Hsp70 in various diseases including the dual and sometimes antagonistic role of this chaperone in various forms of cancer and viral infection including the SARS-Cov-2 case. Since Hsp70 apparently plays an important role in many diseases and pathologies and has significant therapeutic potential there is a dire need to develop cheap recombinant Hsp70 production and further investigate the interaction of externally supplied and endogenous Hsp70 in chaperonotherapy.

Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review.

Rapidly growing interest in using nanoparticles (NPs) for biomedical applications has increased concerns about their safety and toxicity. In comparison with bulk materials, NPs are more chemically active and toxic due to the greater surface area and small size. Understanding the NPs' mechanism of toxicity, together with the factors influencing their behavior in biological environments, can help researchers to design NPs with reduced side effects and improved performance. After overviewing the classification and properties of NPs, this review article discusses their biomedical applications in molecular imaging and cell therapy, gene transfer, tissue engineering, targeted drug delivery, Anti-SARS-CoV-2 vaccines, cancer treatment, wound healing, and anti-bacterial applications. There are different mechanisms of toxicity of NPs, and their toxicity and behaviors depend on various factors, which are elaborated on in this article. More specifically, the mechanism of toxicity and their interactions with living components are discussed by considering the impact of different physiochemical parameters such as size, shape, structure, agglomeration state, surface charge, wettability, dose, and substance type. The toxicity of polymeric, silica-based, carbon-based, and metallic-based NPs (including plasmonic alloy NPs) have been considered separately.

Green Synthesis of Copper Nanoparticles by Using Plant Extracts and their Biomedical Applications – An Extensive Review

In recent years, the green synthesis of different metal nanoparticles has become a substan-tial technique for the synthesis of different essential nanoparticles and their potential applications in technological, industrial along with biomedical fields. Among the several essential nanoparticles, copper nanoparticles (CuNPs) have attracted enormous attention for their wide range of applications like the production of gas sensors, solar cells, high-temperature superconductors as well as drug delivery materials and catalysis owing to its distinctive optical, electrical, dielectric, imaging and catalytic, etc. properties. Herein, in this review, our aim is to find out the recent progress of synthesis, as well as different optical and structural characterizations of green, synthesized CuNPs along with their broad-spectrum biomedical applications, mainly antibacterial, antifungal, antiviral and anticancer as well as the future perspective of research trends in the green synthesis of CuNPs. CuNPs have been synthesized by different researchers using three methods, namely, physical, chemical, and biological. In this review, the eco-friendly, efficient and low cost different established biological/green synthesis methods of CuNPs using different plant extracts like leaves, flowers, fruits, seeds, latex, etc., as capping and reducing agents have been briefly discussed, along with reaction conditions together with their optical as well as structural analysis. Effects of different parameters on the green synthesis of CuNPs like the presence of phytochemicals and confirmation of phytochemicals, temperature, pH, etc., are eluci-dated. Studies of the antibacterial activity of biomolecules capped CuNPs by different researchers against both Gram-positive and Gram-negative bacterial strains along with minimum inhibitory concentration (MIC) values have been summarized. Furthermore, antifungal and antiviral effects of green synthesized CuNPs studied by different researchers are mentioned with minimum inhibitory concentration (MIC) values. The anticancer activity of green synthesized CuNPs against different cancer cells studied by different researchers is summarized with correlation sizes of CuNPs on anticancer activity. The review also focuses on in vivo applications of green synthesized CuNPs along with clinical trails. Furthermore, an emphasis is given to the effectiveness of CuNPs in combating COVID-19. © 2023 Bentham Science Publishers.

Additive manufacturing for biomedical applications: a review on classification, energy consumption, and its appreciable role since COVID-19 pandemic

The exponential rise of healthcare problems like human aging and road traffic accidents have developed an intrinsic challenge to biomedical sectors concerning the arrangement of patient-specific biomedical products. The additively manufactured implants and scaffolds have captured global attention over the last two decades concerning their printing quality and ease of manufacturing. However, the inherent challenges associated with additive manufacturing (AM) technologies, namely process selection, level of complexity, printing speed, resolution, biomaterial choice, and consumed energy, still pose several limitations on their use. Recently, the whole world has faced severe supply chain disruptions of personal protective equipment and basic medical facilities due to a respiratory disease known as the coronavirus (COVID-19). In this regard, local and global AM manufacturers have printed biomedical products to level the supply-demand equation. The potential of AM technologies for biomedical applications before, during, and post-COVID-19 pandemic alongwith its relation to the industry 4.0 (I4.0) concept is discussed herein. Moreover, additive manufacturing technologies are studied in this work concerning their working principle, classification, materials, processing variables, output responses, merits, challenges, and biomedical applications. Different factors affecting the sustainable performance in AM for biomedical applications are discussed with more focus on the comparative examination of consumed energy to determine which process is more sustainable. The recent advancements in the field like 4D printing and 5D printing are useful for the successful implementation of I4.0 to combat any future pandemic scenario. The potential of hybrid printing, multi-materials printing, and printing with smart materials, has been identified as hot research areas to produce scaffolds and implants in regenerative medicine, tissue engineering, and orthopedic implants.

Biogenic Selenium Nanoparticles in Biomedical Sciences: Properties, Current Trends, Novel Opportunities and Emerging Challenges in Theranostic Nanomedicine.

Selenium is an important dietary supplement and an essential trace element incorporated into selenoproteins with growth-modulating properties and cytotoxic mechanisms of action. However, different compounds of selenium usually possess a narrow nutritional or therapeutic window with a low degree of absorption and delicate safety margins, depending on the dose and the chemical form in which they are provided to the organism. Hence, selenium nanoparticles (SeNPs) are emerging as a novel therapeutic and diagnostic platform with decreased toxicity and the capacity to enhance the biological properties of Se-based compounds. Consistent with the exciting possibilities offered by nanotechnology in the diagnosis, treatment, and prevention of diseases, SeNPs are useful tools in current biomedical research with exceptional benefits as potential therapeutics, with enhanced bioavailability, improved targeting, and effectiveness against oxidative stress and inflammation-mediated disorders. In view of the need for developing eco-friendly, inexpensive, simple, and high-throughput biomedical agents that can also ally with theranostic purposes and exhibit negligible side effects, biogenic SeNPs are receiving special attention. The present manuscript aims to be a reference in its kind by providing the readership with a thorough and comprehensive review that emphasizes the current, yet expanding, possibilities offered by biogenic SeNPs in the biomedical field and the promise they hold among selenium-derived products to, eventually, elicit future developments. First, the present review recalls the physiological importance of selenium as an oligo-element and introduces the unique biological, physicochemical, optoelectronic, and catalytic properties of Se nanomaterials. Then, it addresses the significance of nanosizing on pharmacological activity (pharmacokinetics and pharmacodynamics) and cellular interactions of SeNPs. Importantly, it discusses in detail the role of biosynthesized SeNPs as innovative theranostic agents for personalized nanomedicine-based therapies. Finally, this review explores the role of biogenic SeNPs in the ongoing context of the SARS-CoV-2 pandemic and presents key prospects in translational nanomedicine.

Green microwave synthesis of ZnO and CeO2 nanorods for infectious diseases control and biomedical applications.

Control of Infectious diseases such as; bacteria and viruses, has become a globally critical issue, since the appearance of COVID-19 virus in 2020. In addition to the microbial resistance of the currently available therapeutic drugs as well as, its prolonged side effects make its use is of health care concern. Green nanotechnology approach is a promising solution for controlling such infectious diseases and many biomedical purposes. In the present study, green synthesis approach based on microwave-assisted hydrothermal method is an innovative and environmentally friendly method for preparation of bioactive CeO2 and ZnO nanorod structured materials using Olea europaea (O. e.) leaf plant extract as a natural medicinal capping agent for controlling the shape and size of nano-products. The optical and structural analyses of the obtained nanorod-structures are characterized using; TEM, FTIR, XRD, SBET analyses and particle size analyzer. The green-synthesized ZnO and CeO2 nanorods display an average crystallite size of approximately 15 and 5 nm, respectively. The antimicrobial activity of ZnO and CeO2 nanorods compared with the traditional hydrothermal methods, was examined on six clinical pathogens including; (E. coli Serratia sp., S. aureus, Bacillus subtilis, Streptococcus mutant, and MRSA). The results indicated superior antimicrobial and anti-tumor activities towards hepatocellular carcinoma cell lines (IC50 = 117.24 and 103.50 µg mL-1 for ZnO and CeO2 and LD50 > 3000 mg kg-1). This demonstrates that the green microwave process is a promising approach for the synthesis of effective ZnO and CeO2 nanomaterials applied for many biomedical applications.

Molecular modifications, biological activities, and applications of chitosan and derivatives: A recent update.

Polysaccharides arouse great interest due to their structure and unique properties, such as biocompatibility, biodegradability, and absence of toxicity. Polysaccharides from marine sources are particularly useful due to the wide variety of applications and biological activities. Chitosan, a deacetylated derivative of chitin, is an example of an interesting bioactive marine-derived polysaccharide. Moreover, a wide variety of chemical modifications and conjugation of chitosan with other bioactive molecules are responsible for improvements in physicochemical properties and biological activities, expanding the range of applications. An overview of the synthetic approaches for preparing chitosan, chitosan derivatives, and conjugates is described and discussed. A recent update of the biological activities and applications in different research fields, mainly focused on the last 5 years, is presented, highlighting current trends.

Multifunctional surface functionalized magnetic iron oxide nanoparticles for biomedical applications: A review

Magnetic iron oxide nanoparticle-based multifunctional platforms have been explored extensively in biomedical applications. Modifications and integrations of IONPs with different entities viz. organic polymer, doping with inorganic materials, loading with drug, fluorescent dye, or antibodies make them appropriate for their application in broad spectrum of biomedical fields. This review presents and summarizes the fabrication strategies of multifunctional magnetic nanoparticles based on the modification and surface functionalization of MNP. Multifunctional IONPs based recent advances covering a wide array of applications like biosensing and pathogen detection, magnetic resonance imaging (MRI) and biomarker tracking, magnetofection and gene therapy, hyperthermia and chemotherapy, drug delivery and targeted cell killing, bioimaging and therapeutics, stem cell detection and therapy, tissue engineering and organ transplant, nano-vaccines and immune system activation, microbe targeting and destruction, and COVID19 management are also covered.

Green synthesis of ZrO2 nanoparticles and nanocomposites for biomedical and environmental applications: a review.

Pollution and diseases such as the coronavirus pandemic (COVID-19) are major issues that may be solved partly by nanotechnology. Here we review the synthesis of ZrO2 nanoparticles and their nanocomposites using compounds from bacteria, fungi, microalgae, and plants. For instance, bacteria, microalgae, and fungi secret bioactive metabolites such as fucoidans, digestive enzymes, and proteins, while plant tissues are rich in reducing sugars, polyphenols, flavonoids, saponins, and amino acids. These compounds allow reducing, capping, chelating, and stabilizing during the transformation of Zr4+ into ZrO2 nanoparticles. Green ZrO2 nanoparticles display unique properties such as a nanoscale size of 5-50 nm, diverse morphologies, e.g. nanospheres, nanorods and nanochains, and wide bandgap energy of 3.7-5.5 eV. Their high stability and biocompatibility are suitable biomedical and environmental applications, such as pathogen and cancer inactivation, and pollutant removal. Emerging applications of green ZrO2-based nanocomposites include water treatment, catalytic reduction, nanoelectronic devices, and anti-biofilms.

Biocompatible Conductive Hydrogels: Applications in the Field of Biomedicine.

The impact of COVID-19 has rendered medical technology an important factor to maintain social stability and economic increase, where biomedicine has experienced rapid development and played a crucial part in fighting off the pandemic. Conductive hydrogels (CHs) are three-dimensional (3D) structured gels with excellent electrical conductivity and biocompatibility, which are very suitable for biomedical applications. CHs can mimic innate tissue's physical, chemical, and biological properties, which allows them to provide environmental conditions and structural stability for cell growth and serve as efficient delivery substrates for bioactive molecules. The customizability of CHs also allows additional functionality to be designed for different requirements in biomedical applications. This review introduces the basic functional characteristics and materials for preparing CHs and elaborates on their synthetic techniques. The development and applications of CHs in the field of biomedicine are highlighted, including regenerative medicine, artificial organs, biosensors, drug delivery systems, and some other application scenarios. Finally, this review discusses the future applications of CHs in the field of biomedicine. In summary, the current design and development of CHs extend their prospects for functioning as an intelligent and complex system in diverse biomedical applications.

2D MXenes for Combatting COVID-19 Pandemic: A Perspective on Latest Developments and Innovations

The COVID-19 pandemic has adversely affected the world, causing enormous loss of lives. A greater impact on the economy was also observed worldwide. During the pandemic, the antimicrobial aprons, face masks, sterilizers, sensor processed touch-free sanitizers, and highly effective diagnostic devices having greater sensitivity and selectivity helped to foster the healthcare facilities. Furthermore, the research and development sectors are tackling this emergency with the rapid invention of vaccines and medicines. In this regard, two-dimensional (2D) nanomaterials are greatly explored to combat the extreme severity of the pandemic. Among the nanomaterials, the 2D MXene is a prospective element due to its unique properties like greater surface functionalization, enhanced conductivity, superior hydrophilicity, and excellent photocatalytic and/or photothermal properties. These unique properties of MXene can be utilized to fabricate face masks, PPE kits, face shields, and biomedical instruments like efficient biosensors having greater antiviral activities. MXenes can also cure comorbidities in COVID-19 patients and have high drug loading as well as controlled drug release capacity. Moreover, the remarkable biocompatibility of MXene adds a feather in its cap for diverse biomedical applications. This review briefly explains the different synthesis processes of 2D MXenes, their biocompatibility, cytotoxicity and antiviral features. In addition, this review also discusses the viral cycle of SARS-CoV-2 and its inactivation mechanism using MXene. Finally, various applications of MXene for combatting the COVID-19 pandemic and their future perspectives are discussed.

35 years in plant lectin research: a journey from basic science to applications in agriculture and medicine.

Plants contain an extended group of lectins differing from each other in their molecular structures, biochemical properties and carbohydrate-binding specificities. The heterogeneous group of plant lectins can be classified in several families based on the primary structure of the lectin domain. All proteins composed of one or more lectin domains, or having a domain architecture including one or more lectin domains in combination with other protein domains can be defined as lectins. Plant lectins reside in different cell compartments, and depending on their location will encounter a large variety carbohydrate structures, allowing them to be involved in multiple biological functions. Over the years lectins have been studied intensively for their carbohydrate-binding properties and biological activities, which also resulted in diverse applications. The present overview on plant lectins especially focuses on the structural and functional characteristics of plant lectins and their applications for crop improvement, glycobiology and biomedical research.

Investigating Novel Coronavirus Through Statistical Methods for Biomedical Applications: An Engineering Student Perspective

The World of today is suffering from novel coronavirus (nCOV2). This is a respiratory infectious disease that has affected the entire globe. This respiratory infection is first originated in Wuhan, China. Today, it has many variants like the “United Kingdom (UK) variant called B.1.1.7,” “South African variant is called B.1.351,” “Brazilian variant is known as P.1,” etc. In this research work, we will discuss the Indian scenario to tackle nCOV2. We will also present an engineering student’s perspective to detect changes developed in the patient’s chest suffering from nCOV2 employing statistical methods. Among all the statistical techniques, GLCM-based texture analysis-based technique has gained popularity due to its diverse applications. It is used in many applications like remote sensing, image processing, biomedical applications, seismic data analysis. Thus in this research work, this methodology is used various changes in the before and after images of the patient suffering from the novel coronavirus. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

Biomedical Applications of Terahertz Near-field Imaging

We demonstrate the THz near-field nano-imaging of Bacillus cereus and Corona Virus Disease 2019 (COVID-19) spike fake virus utilizing THz scattering near-field optical microscopy (SNOM). Here, it shows that bacteria and virus can be distinguished from other substances by THz near-field imaging. And we can use the THz time-domain spectrometer (TDS) scattering near field microscope(s-SNOM) to obtain the spectrum of different substances (bacteria and their substrate), then analyzing the differences between them from their specific responses in THz. This is of great significance to development of the terahertz near-field biology. © 2021 European Union

From Biomedical Applications of Alginate towards CVD Implications Linked to COVID-19.

In the past year, researchers have focused their attention on developing new strategies for understanding how the coronavirus affects human health and developing novel biomaterials to help patients with cardiovascular disease, which greatly increases the risk of complications from the virus. Natural biopolymers have been investigated, and it has been proven that alginate-based materials have important features. This review presents an overview of alginate-based materials used for developing innovative biomaterial platforms for biomedical applications to mitigate the effects of the coronavirus. As presented in this review, COVID-19 affects the cardiovascular system, not only the lungs. The first part of the review presents an introduction to cardiovascular diseases and describes how they have become an important problem worldwide. In the second part of the review, the origin and unique properties of the alginate biopolymer are presented. Among the properties of alginate, the most important are its biocompatibility, biodegradability, low cost, nontoxicity, unique structure, and interesting features after chemical modification. The third section of the review illustrates some of the functions of alginate in biomedical, pharmaceutical, and drug delivery applications. Researchers are using alginate to develop new devices and materials for repairing heart tissues that have been damaged by the coronavirus. Further, insights regarding how cardiovascular disease affects COVID-19 patients are also discussed. Finally, we conclude the review by presenting a summary of the impacts of COVID-19 on cardiovascular patients, their implications, and several hypothetical alginate-based treatments for infected patients.

Antimicrobial sustainable biopolymers for biomedical plastics applications - an overview

The Covid-19 pandemic has increased the need for personal protective equipment (PPE), especially for medical personnel: face masks, full protective clothing, gloves and goggles. To date, they are usually made of thermoplastic polymers, such as polypropylene (PP). To reduce the risk of secondary infections it is essential to enhance the antimicrobial (especially antibacterial and antiviral) properties of the materials used in PPE. There are some attempts to modify materials by, for example, silver nanoparticles or zinc oxides. The increasing demand for personal protective equipment, mostly masks, leads to an increase of environmental problem of non-biodegradable wastes. Therefore some researches on use of safer for user's health sustainable antimicrobial and biodegradable biopolymer fibers, such as cellulose, starch, chitosan, poly(lactic acid) (PLA) or poly(glycolic acid) (PGA), have been done. These biopolymers and their properties are discussed in this article.

Multifunctional cold spray coatings for biological and biomedical applications: A review

A variety of coating techniques are available for medical devices to be tailored with surface properties aimed at optimizing their performance in biological environments. Cold spray, as a member of the thermal spray family, is now being exploited to efficiently deposit micro- to nanometer sized metallic or non-metallic particles on surgical implants, medical devices and surfaces in the healthcare environment to create functional coatings. Cold spray has attracted attention in the context of biomedical applications due to the fact that multiple materials can be combined easily at the surface of these devices, and that oxygen-sensitive and heat-sensitive organic molecules, including bioactive compounds, can be incorporated in these coatings due to the relatively low temperatures used in the process. The ability to maintain material and chemical properties and the ability to create functional coatings make the cold spray process particularly suitable for applications in the MedTech industry sector. This review explores the fabrication of cold spray coatings including the types of materials that have been used for biomedical purposes, provides a detailed analysis of the factors affecting cold spray coating performance, and gives an overview over the most recent developments related to the technology. Cold spray coatings that have been used until this point in time in biomedical applications can be broadly classified as biocompatible coatings, anti-infective coatings, anti-corrosive coatings, and wear-resistant coatings. In addition, this review discusses how these applications can be broadened, for example by providing antiviral effect against coronavirus (COVID-19). While we highlight examples for multifunctional cold spray coatings, we also explore the current challenges and opportunities for cold spray coatings in the biomedical field and predict likely future developments.